产品货号：
Z34832
中文名称：
LGR5抗体
英文名称：
Anti-LGR5 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LGR5 Antibody |
| 指标别名 | leucine rich repeat containing G protein-coupled receptor 5;FEX;GPR49;GPR67;GRP49;HG38;LGR5 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IP,FCM |
| 基因名称 | LGR5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human LGR5/GPR49 |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Leucine?rich repeat G?protein?coupled receptor 5 (Lgr5),also called GPR49,is a 907 amino acid (aa),approximately 97kDa (calculated),seven?transmembrane glycoprotein receptor in the Lgr family of cell surface receptors.The subfamily of Lgrs comprising Lgr4,Lgr5,and Lgr6 are G?protein?independent mediators of the potentiating effect of R?Spondins on Wnt signaling (2).Lgr5 binds and forms complexes with R?Spondins,Frizzled Wnt receptors and LRP Wnt co?receptors.The region of the human Lgr5 long extracellular domain used as an immunogen shares 90% amino acid sequence identity with mouse and rat Lgr5,respectively.Lgr5 is found on embryonic and adult epithelial stem cells (3).Lgr5+ stem cells can produce all epithelial cell types of the intestinal crypts (4).Abnormal LGR5 expression and regulation in stem cells might give rise to cancers such as intestinal,hepatocellular,pancreatic and ovarian carcinomas (5,6).This antibody has been referred to as "RD42" in Peng et al.(1). |
| Uniprot ID | O75473 |
| 基因名全称 | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| 蛋白名全称 | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocoprecipitation 1:20 Flow cytometry (FCM) 1:20 |
相关搜索：LGR5抗体，LGR5单抗，Anti-LGR5 Antibody